The 48-month follow-up results of the prospective, multi-centre study of Contura's longer lasting filler conducted in six European countries have been presented by Dr. Hermann Lampe, Germany at IMCAS, Paris in January 2007.

82 patients were available for evaluation, and the aesthetic results were judged to be good or very good in more than 90% of the cases by the investigators. More than 90% of the patients were either satisfied or very satisfied with the aesthetic results after 48 months.

Of the 82 patients who completed the 48-month follow-up, 50 patients had not been re-injected at any of the follow-up visits since the beginning of the study. A total of 98% of these 50 patients were still satisfied with their aesthetic results at the 48-month follow-up. Results were judged to be good or very good by the investigators in 98% of the patients not re-injected.

There was no difference in efficacy between the 12, 24 and 48-month follow-up.

Adverse events related to the treatment were mostly mild or moderate local reactions to the injection. One possibly related adverse event was reported between the 24-month and 48-month follow-up. It was an infection that was resolved with antibiotic treatment.

The follow-up period of the prospective study is 60 months.

The 48-month results further strengthens the clinical documentation of Contura's longer lasting filler as a safe, non-absorbable soft-tissue filler providing lasting aesthetic results.